Cancer Wars: Revenge of the AMPs (Antimicrobial Peptides), a New Strategy against Colorectal Cancer

Cancer is a multifaceted health issue that affects people globally and it considered one of the leading causes death with high percentage victims worldwide. In recent years, research studies have uncovered great advances in cancer diagnosis treatment. But, there are still major drawbacks conventional therapies used including severe side effects, toxicity, drug resistance. That why critical to develop new drugs advantages like low cytotoxicity no treatment resistance cells. Antimicrobial peptides (AMPs) recently attracted attention as novel therapeutic strategy for various cancers, targeting tumor cells less toxicity normal tissues. The aim study was discover alternate treatments do not lead fewer effects. Here, we report effects induced by several AMPs, Melittin, Cecropin A, A—Melittin hybrid, against two human colorectal cancer-derived spheroids. To peptides, cell viability investigated using MTT, LDH, ATP assays. Furthermore, cellular senescence cycle were investigated. We found different concentrations these affected spheroids, their structure being highly compromised reducing viability, increase LDH levels. Also, arrested G2/M phase an senescent show Melittin hybrid most effective 3D compared A.